Get Amorphous Solid Dispersions: Theory and Practice (Advances PDF

By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick

This quantity deals a finished advisor at the thought and perform of amorphous reliable dispersions (ASD) for dealing with demanding situations linked to poorly soluble medicinal drugs. In twenty-three inclusive chapters, the publication examines thermodynamics and kinetics of the amorphous country and amorphous strong dispersions, ASD applied sciences, excipients for stabilizing amorphous reliable dispersions akin to polymers, and ASD production applied sciences, together with spray drying, sizzling soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation know-how (MBP). every one know-how is illustrated by means of particular case experiences. furthermore, committed sections conceal analytical instruments and applied sciences for characterization of amorphous good dispersions, the prediction of long term balance, and the advance of compatible dissolution equipment and regulatory points. The ebook additionally highlights destiny applied sciences at the horizon, akin to supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.

Amorphous stable Dispersions: conception and perform is a necessary connection with pharmaceutical scientists drawn to constructing bioavailable and therapeutically powerful formulations of poorly soluble molecules to be able to develop those applied sciences and boost higher medications for the future.

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Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology) by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick


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