By Michael J. Barratt,Donald E. Frail
The how's and why's of winning drug repositioning
Drug repositioning, sometimes called drug reprofiling or repurposing, has develop into an more and more vital a part of the drug improvement method. This ebook examines the enterprise, technical, clinical, and operational demanding situations and possibilities that drug repositioning deals. Readers will tips on how to practice the most recent experimental and computational tools that help drug repositioning, and specific case stories during the e-book reveal how those tools healthy in the context of a entire drug repositioning strategy.
Drug Repositioning is split into 3 parts:
Part 1, Drug Repositioning: company Case, options, and Operational Considerations, examines the scientific and advertisement drivers underpinning the search to reposition latest medications, guiding readers in the course of the key strategic, technical, operational, and regulatory judgements wanted for profitable drug repositioning programs.
Part 2, program of know-how structures to discover New symptoms and Repurpose latest Drugs, units forth computational-based options, instruments, and databases which have been designed for repositioning reports, screening methods, together with mixtures of present medications, and a glance on the improvement of chemically converted analogs of authorized agents.
Part three, educational and Non-Profit projects & the function of Alliances within the Drug Repositioning Industry, explores present investigations for repositioning medicinal drugs to regard infrequent and overlooked ailments, that are usually missed by way of for-profit pharmaceutical businesses because of their loss of advertisement return.
The book's appendix offers helpful assets for drug repositioning researchers, together with info on drug repositioning and reformulation businesses, databases, executive assets and companies, regulatory corporations, and drug repositioning projects from academia and non-profits.
With this ebook as their consultant, scholars and pharmaceutical researchers can the way to use drug repositioning recommendations to increase the lifespan and functions of present medications in addition to maximize the go back on funding in drug examine and development.
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Extra info for Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs
Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs by Michael J. Barratt,Donald E. Frail