By Ming-Ming Zhou
This publication presents a well timed overview of the position of histone ameliorations in epigenetic keep an eye on of gene expression. subject matters coated contain: simple mechanisms of molecular acceptance of histone post-translational amendment (PTMs); combinatorial readout of histone PTMs via tandem epigenome reader domain names; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their power as a brand new method of healing intervention in human illnesses. All chapters have been written by way of prime scientists who made the unique key discoveries of the constitution and mechanism of evolutionarily conserved reader domain names, which serve to direct gene transcription in chromatin via interactions with DNA-packing histones in a PTM-sensitive manner.
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Histone Recognition by Ming-Ming Zhou
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